| Biological Sciences in Public Health |
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Programs and DisciplinesBIOLOGICAL SCIENCES IN PUBLIC HEALTH (BPH) PROGRAM
• Molecular & Integrative Physiological Sciences, including pulmonary inflammation, pneumonia and asthma toxicity and pathophysiology of air pollution bioengineering, biophysics • Molecular Mechanisms of Adaptive Responses to Stress IMMUNOLOGY & INFECTIOUS DISEASES • Immunology • Nutritional Biochemistry The Program in Biological Sciences in Public Health (BPH) was established at Harvard University in 1993. The program trains a cadre of leaders who, while possessing expertise in the individual fields of biological research, also possess a broad interdisciplinary knowledge of epidemiology and biostatistics. The program trains research scientists in the following areas of cellular and molecular biology: nutritional biochemistry; cardiovascular biology; gene regulation; cell/ environment interactions; toxicology; cancer; pulmonary inflammation; immunology; infectious diseases: protozoa, helminths, viruses and bacteria; genetic approaches to disease mechanisms. Students apply cutting-edge technology to the solution of world-wide problems with a focus toward better treatment and prevention of human diseases. It has become increasingly evident that progress in disease prevention is optimally promoted by a close interaction between epidemiologists and laboratory scientists, where laboratory discoveries and epidemiological observations interact in an iterative manner to advance research in both fields. This program includes faculty from the school’s Departments of Genetics and Complex Diseases, Environmental Health, Immunology and Infectious Diseases and Nutrition, in addition to faculty at Harvard Medical School and other Harvard associated institutions. This interdisciplinary program fosters a stimulating and supportive environment for research training in the biomedical sciences. The BPH program is rooted in the rich and diverse environment of the Harvard School of Public Health, which is dedicated to advancing the public’s health through learning, discovery, and communication. The School’s research and training programs emphasize the following objectives: • to provide the highest level of education to public health scientists, practitioners, and leaders; • to foster new discoveries leading to improved health for the people of this country and all nations; • to strengthen health capacities and services for communities; and • to inform policy debate, disseminate health information, and increase awareness of public health as a public good and fundamental right.
The field of public health is inherently multi-disciplinary and so, too, are the interests and expertise of the School’s faculty and students, which extend across the biological, quantitative, and social sciences. With our roots in biology, we are able to confront the most pressing diseases of our time—AIDS, cancer, and heart disease—by adding to our knowledge of their underlying structure and function. Core quantitative disciplines like epidemiology and biostatistics are fundamental to analyzing the broad impact of health problems, allowing us to look beyond individuals to entire populations. And, because preventing disease is at the heart of public health, we also pursue the social sciences to better understand health-related behaviors and their societal influences—critical elements in educating and empowering people to make healthier lifestyle choices. From advancing scientific discovery to training national and international leaders, the Harvard School of Public Health has been at the forefront of efforts to benefit the health of populations worldwide. Shaping new ideas in our field and communicating them effectively will continue to be priorities in the years ahead as we serve society’s changing health needs. Founded in 1922, the Harvard School of Public Health was the nation’s first graduate training program in public health. Early pioneers at the school included Alice Hamilton, who elucidated the health effects of lead and other industrial toxins; Philip Drinker, whose iron lung sustained the lives of many stricken with paralytic polio; Thomas Weller, whose Nobel Prize-winning research paved the way for the development of polio vaccines; and Bernard Lown, co-founder of the Nobel Prize-winning organization International Physicians for the Prevention of Nuclear War.
Research FacilitiesLocated in the Longwood Medical Area of Boston, the program brings together faculty in the biological sciences throughout Harvard University. The Medical Area, which includes the Harvard School of Public Health, Harvard Medical School, and a cluster of hospitals, comprises one of the most concentrated areas of scientific research facilities in the United States. The interaction of faculty working at associated institutions, through joint teaching and research, enables the program to serve as a meeting place for the biological, medical, physical, and chemical scientists. This provides students and faculty alike with a wider range of experience and techniques than may be found in any single discipline or department. At the Harvard School of Public Health alone, modern research laboratories are housed on 14 floors of three buildings. Students have access to the Countway Library, one of the most complete biomedical research collections in the nation. The main Harvard University campus in Cambridge encompasses a wide variety of strong academic departments and facilities in the humanities and sciences. The program specifically interacts with the biological sciences programs in molecular and cellular biology, organismic and evolutionary biology, and biophysics.
Program of StudyThe program offers opportunities in a wide range of laboratory experiences and considerable interaction among the program components. Academic programs fulfill needs and goals through core and advanced courses, seminars, rotations in laboratories, and a qualifying examination. Courses may be chosen from the offerings of Harvard University as well as from those of the Massachusetts Institute of Technology. Rotations are an integral part of each program; they allow students to investigate several types of research and laboratories before choosing a dissertation laboratory. Students choose a dissertation laboratory by the end of the first year. Although individual programs vary, generally students take a qualifying examination during their second year. After successful completion of the qualifying examination, the dissertation advisor supervises the doctoral candidate’s research and study, with an advisory committee periodically reviewing progress. Typically, about four years of laboratory work are needed to complete the dissertation research, which is defended before three examiners. Generally, students complete the degree in five to six years.
The Informal CurriculumOutside of the classroom, the program sponsors a variety of activities that bring together students and faculty with a broad range of research interests. Important elements of this “informal curriculum” are the seminars, journal clubs, and retreats. These sessions give students the chance to interact with faculty and postdoctoral fellows from laboratories throughout the Medical Area, and to learn about research in diverse fields. Student-run journal clubs and seminars provide opportunities to learn how to give talks, critically evaluate scientific literature, present data, and take part in group discussions. Each year students organize their own symposium with talks and poster sessions. City-wide seminars draw researchers from all area institutions into a larger scientific community. Some students serve for at least one term as teaching assistants for graduate and medical school classes, or for undergraduate courses taught in Cambridge. Student organizations plan various social and academic activities.
Combined Degree ProgramsThe program, in conjunction with Harvard Medical School, offers a combined MD/PhD program to train physician-scientists to work at the forefront of biomedical research and to provide an interface between the most basic and technical research and its clinical application at the bedside. The program seeks to provide students with the most thorough and up-to-date medical education and training for research careers. Students who are interested in working toward simultaneous MD and PhD degrees should complete the application for admission to Harvard Medical School and the MD/PhD Program.
AdmissionsTo apply to the PhD Program in Biological Sciences in Public Health (program #8500), Graduate School of Arts and Sciences admissions forms must be used. Completed applications must be submitted directly to the Graduate School of Arts and Sciences by the December 8 deadline. We encourage online submission of the application. See www.gsas. harvard.edu. (To apply for all other degrees [SD, DPH, MPH, SM, MOH] offered by the Harvard School of Public Health, Harvard School of Public Health admissions forms must be used. Completed applications must be submitted to the School of Public Health by the designated deadline.) To qualify for admission, applicants must demonstrate strong enthusiasm and ability for the vigorous pursuit of scientific knowledge. Minimal requirements include a bachelor’s degree and undergraduate preparation in calculus, physics, biology, and chemistry, both physical and organic. Strong consideration is given to letters of recommendation, particularly to comments from individuals who have firsthand knowledge of the applicant’s research experience. Some programs may request a personal interview. A completed application includes the application form, fee, statement of purpose, summary form, three letters of recommendation, scores from the Graduate Record Examination (General Test), and transcripts. Applicants whose native language is not English and who have not received a degree from an English language institution must score at least 600 on the Test of English as a Foreign Language (TOEFL). All materials, including letters of recommendation and official reports of the Graduate Record Examination (GRE), must be received by the December 8 deadline. GRE tests should be taken no later than November for official scores to arrive in time. Applicants wishing to do research in immunology and infectious diseases; genetic and molecular mechanisms of chronic diseases (cancer, diabetes, obesity); nutritional biochemistry; bioengineering or molecular and integrative physiology usually apply to the Biological Sciences in Public Health (BPH) program. In addition to the programs described here, the Graduate School of Arts and Sciences offers the Harvard Integrated Live Science (HILS) Programs: Academic areas represent the depth and breadth of current thinking in the life sciences. Each of the HILS program provides research opportunities in basic life sciences. HILS supports programs leading to the PhD in: • biological and biomedical sciences (an umbrella program that covers multiple disciplines) Academic benefits include full access to faculty throughout the University— approximately 500 life sciences faculty—and to training resources of the entire University: abundant opportunities to participate in new interdisciplinary areas of study as they develop; freedom to move among programs, subject to specific program requirements and lab availability; integrated research opportunities, including seminars with top faculty and workshops. Harvard University’s policy is to make decisions on the basis of the individual’s qualifications to contribute to Harvard’s educational objectives and institutional needs. It is unlawful, and contrary to Harvard University policy, to discriminate against individuals on the basis of race, color, gender, sexual orientation, religion, age, national or ethnic origin, political beliefs, veteran status, or disability unrelated to job or course of study requirements.
Financial Aid and Cost of StudyStudents receive full tuition and stipend support while they are enrolled and making satisfactory progress toward the PhD degree. International applicants are urged to seek financial support from their national governments and fellowship agencies. Limited international student funding is available from the University’s Presidential Fund and corporate-sponsored fellowships awarded to Harvard for students from developing central African countries. The program strongly encourages applicants to apply for support from extramural agencies. Students who receive competitively funded extramural fellowships may be eligible to receive an educational allowance from the division.
Life in BostonThe Harvard School of Public Health is located in the Longwood Medical Area of Boston, across the Charles River from Cambridge. The two cities offer a geographically compact, yet rich and varied academic and cultural environment. Forty-three colleges and universities in the metropolitan area sponsor a multitude of cultural and intellectual activities, all easily accessible via public transportation. The close proximity to MIT, the natural science departments in Cambridge, and the medical schools at Boston University and Tufts University provides an unusual concentration of scientific research that draws visiting scientists from around the world. The main Harvard campus in Cambridge supports a wide variety of facilities for athletics and graduate student activities. Students have access to all the libraries of Harvard University, which is the largest university library system in the world. In addition to a long list of renowned institutions, such as the Museum of Science and the Museum of Fine Arts, Boston itself is a museum, with hundreds of historical sites and an exciting range of architectural styles as well as ethnically diverse neighborhoods offering an international flavor. Recreational opportunities in the Boston area are many and varied. Sports fans can follow the Patriots, Bruins, Celtics, or the Red Sox—Fenway Park is only a short walk from Harvard Medical School. Within the city, the Charles River offers an afternoon of sailing and windsurfing, while the network of parks known as the “Emerald Necklace” winds its way from Kenmore Square, through Olmsted Park and past Jamaica Pond to the 265-acre Arnold Arboretum, which is both a city park and a Harvard research facility. Walden Pond and the Great Meadows Wildlife Refuge in Concord are within biking distance. The beaches of Cape Cod, and skiing, hiking, and camping in the Berkshires, Vermont, New Hampshire, and Maine are accessible in day trips.
The Longwood Medical AreaImmediately adjacent to the Harvard School of Public Health, are the Harvard Medical School, the Countway Medical Library, one of the most complete biomedical research collections in the country, and the research laboratories of seven affiliated hospitals and institutes. A free shuttle bus links the area with MIT and Harvard Square in Cambridge. Many students live near the Medical School or in neighboring Brookline; others find affordable housing elsewhere in Boston or in Cambridge. Harvard University provides dormitories for married students and graduate students in Cambridge. University housing is also available for single students in Vanderbilt Hall in the Medical Area, along with athletic facilities and a branch of the Harvard University Health Services. The Harvard School of Public Health houses the program offices as well as a graduate student lounge and computer facilities.
Programs and Disciplines The department-affiliated BPH program components at the Harvard School of Public Health are described below. ENVIRONMENTAL HEALTH Bioengineering This concentration integrates a range of scientific disciplines, including physics, bioengineering, physiology, biomathematics, cell biology, molecular biology, clinical science, and epidemiology. By working within this rich interdisciplinary environment, students learn many measurement technologies, discover a variety of disciplinary approaches, and develop mature scientific thinking. Special facilities are available, including a confocal microscope, analytical electron microscopes, a flow cytometer, a sleep laboratory, and a sensation laboratory. The program is designed to prepare students for research careers in respiratory physiology, cell and molecular biology, or bioengineering. Graduates ordinarily assume positions as faculty members and research scientists in graduate schools, medical schools, research institutes, or schools of public health. Career opportunities in the biological sciences as they apply to public health are expected to grow in academia and in the biotechnology and pharmaceutical industries.
GENETICS AND COMPLEX DISEASESThe complex interplay of biological processes with environmental factors as they apply to chronic, multigenic, and multifactorial diseases is the focus of the new Department of Genetics and Complex Diseases. Department faculty, drawn from the former Department of Cancer Cell Biology and the Department of Nutrition, aim to elucidate the molecular mechanisms underlying the intricate interaction between genetic determinants and their divergent responses to environmental signals to affect the health of human populations. Research focuses on several broad categories, including stress and inflammatory signaling, molecular transport, and genomic instability. The diseases under study include obesity, diabetes, cardiovascular diseases, cancer, and aging, both at the mechanistic level and in the context of population studies. Department faculty are involved in multidisciplinary collaborations with faculty members in other HSPH departments and Harvardaffiliated centers as well as other institutions.
IMMUNOLOGY AND INFECTIOUS DISEASESThe Department of Immunology and Infectious Diseases focuses on the biological, immunological, epidemiological, and ecological aspects of viral, bacterial, protozoan, and helminthic diseases of animals and humans and the vectors that transmit some of these infectious agents. Research in the Department of Immunology and Infectious Diseases emphasizes basic pathogenic mechanisms that may lead to better diagnostic tools, the development of vaccines and other immune interventions for prevention and control of infection and disease, and the identification of new targets for antiviral and antiparasite drugs. Laboratory-based research within the school may be supplemented by field-based studies of epidemi ological and ecological aspects of infectious disease transmission and control. Diseases of developing countries are emphasized. Members of the department take a multidisciplinary approach to infectious diseases, which includes immunology, molecular biology, public health entomology, cell biology and ultrastructure, biochemistry, pathology, virology, epidemiology, and ecology. They undertake research both within the school and around the world. Infectious diseases currently under study by these methods include protozoa (malaria, leishmania, ameba, giardia); helminths (schistosomes, filaria, onchocerca); viruses (HIVs, hepatitis, leukemia retroviruses, and eastern equine encephalitis); and bacteria (Lyme disease agents, ehrlichia, and tuberculosis). Further immunologic studies focus on genetic regulation of the immune response; molecular mechanisms of the regulation of class II genes; the function and regulation of T-cell-derived cytokines; and cytokines involved in the regulation of inflammation.
Graduates ordinarily assume positions as faculty members and research scientists in graduate schools, medical schools, research institutes, or schools of public health. Career opportunities in the biological sciences as they apply to public health are expected to grow in academia and in the biotechnology and pharmaceutical industries.
NUTRITIONThe mission of the Department of Nutrition is to improve human health through enhanced nutrition. The department strives to accomplish this goal through research aimed at improved understanding of how diet influences health, the dissemination of new knowledge about nutrition to health professionals and the public, the development of strategies to enhance nutrition, and the education of researchers and practitioners. The Department of Nutrition provides training and research opportunities in basic science relating to nutrition and in epidemiologic aspects of nutrition as they affect public health. Nutrition policy and the evaluation of nutritional interventions are long-standing interests of the department, particularly as they concern the populations of Latin America, Africa, Asia, and the United States. Interests of the department range from molecular biology to human studies of cancer and heart disease. Students learn and use the latest techniques in biochemistry, physiology, biostatistics, epidemiology, and related fields. Departmental research, whether basic or applied, is relevant to human health. Current research covers a wide range of topics, including large prospective studies of dietary factors in relation to heart disease, cancer, diabetes, and ophthalmologic disease; development of methods to assess nutritional status by an analysis of body tissue; the interaction of nutritional factors with genetic determinants of disease; the interaction of nutritional factors and infectious agents; nutritional influence on blood pressure; effects of nutrition programs on the mental and physical consequences of malnutrition; nutritional determinants of blood lipid factors; lipoprotein metabolism; molecular mechanisms of diabetes and obesity and regulation of the intra- and inter-cellular delivery of macromolecular nutrients; determinants of blood lipid factors, lipoprotein metabolism; molecular mechanisms of diabetes and obesity; regulation of the intraand-inter-cellular delivery of macromolecular nutrients; and the molecular mechanisms leading to atherosclerosis and thrombosis. Graduates ordinarily assume positions as faculty members and research scientists in graduate schools, medical schools, research institutes or schools of public health. Career opportunities in the biological sciences as they apply to public health are expected to grow in academia and in the biotechnology and pharmaceutical industries.
Important Addresses and Numbers Information, program brochures, and application booklets may be requested from any of the following sources. Program AddressesOnline application submissions are encouraged using the Graduate School of Arts and Sciences application form found online. To request hard copy of the Graduate School of Arts and Sciences application form, please visit the website. Office of Admissions and Financial Aid Applicants with specific questions about the program may contact Mrs. Ruth Kenworthy, administrator, Division of Biological Sciences. Biological Sciences in Public Health Program Office Note: Graduate School of Arts and Sciences admissions forms must be used to apply for this program and must be submitted directly to the Graduate School of Arts and Sciences by the December 7 deadline. Addresses for Constituent Departments at Harvard School of Public Health:Genetics and Complex Diseases Environmental Health/Physiology Immunology and Infectious Diseases Nutrition MD/PhD Program
Additional, Related Programs at Harvard UniversityAdmissions Office For the PhD in Biophysics or Organismic and Evolutionary Biology Office of Admissions and Financial Aid Department of Molecular and Cellular Biology
Outside Harvard InformationGraduate Record Examinations (GRE) Test of English as a Foreign Language (TOEFL) PROGRAM IN BIOLOGICAL SCIENCES IN PUBLIC HEALTH PROGRAM COMPONENTS: Genetics and Complex Diseases (GCD) Immunology and Infectious Diseases (IMI) Immunology Nutrition (NUT) Nutritional Biochemistry
ASSOCIATED HARVARD INSTITUTIONS OF BPH FACULTY(DFCI) Dana Farber Cancer Institute
FacultyBarry R. Bloom PhD, Dean of the Faculty and Professor of Immunology and Infectious Diseases, HSPH (BPH) Study of pathogenesis and protection in tuberculosis and development of vaccines. Joseph David Brain SDHYG, Cecil K. and Philip Drinker Professor of Environmental Physiology in the Faculty of Public Health, Emeritus, HSPH (BPH) Function and structure of pulmonary and hepatic macrophages; responses to inhaled gases and particles. Barbara Burleigh PhD, Associate Professor of Immunology and Infectious Diseases, HSPH (BPH) Studies of the molecular basis of host cell invasion, signaling and differentiation by the human pathogen, Trypanosoma cruzi. Hannia Campos PhD, Senior Lecturer on Nutrition, HSPH (BPH) Role of dietary and genetic factors affecting lipoprotein metabolism; development of coronary heart disease. David Christopher Christiani MD, Professor of Occupational Medicine and Epidemiology; Professor of Medicine, HSPH (BPH) Assessment of the impact of workplace pollutants on health. Bruce Demple PhD, Professor of Toxicology, HSPH (BPH) Cellular responses to free radicals: gene regulation and repair of damaged DNA. Douglas Dockery, DSc Professor of Environmental Epidemiology, HSPH (BPH) Manoj Duraisingh PhD, Assistant Professor of Immunology and Infectious Diseases, HSPH (BPH, IID) Molecular mechanisms under lying the pathogenesis of human malaria. Raymond Erikson PhD, American Cancer Society Professor of Cellular and Developmental Biology, HU (BPH, IMI/V) Protein phosphorylation and gene expression in normal and transformed cells. Myron E. Essex DVM, PhD, Mary Woodard Lasker Professor of Health Sciences, HSPH (BPH, IMI/V) Study of human and primate T-lymphotrophic retroviruses, including agents that cause AIDS. Sarah Fortune MD, Assistant Professor of Immunology and Infectious Diseases, HSPH (BPH-IMI) Secretion and pathogenesis in M. tuberculosis. Jeffrey J. Fredberg PhD, Professor of Bioengineering and Physiology, HSPH (BPH) Laurie H. Glimcher MD, Professor of Medicine, BWH; Irene Heinz Given Professor of Immunology, HSPH (BPH, IMI) Class II MHC function, structure and regulation; T helper cell development cytokine gene transcriptions. Marcia B. Goldberg MD, Associate Professor of Medicine, HMS (BPH, IMI) Host-pathogen interactions of Shigella. Michael Grusby PhD, Professor of Molecular Immunology in the Faculty of Public Health, Professor of Medicine, HSPH (BPH, IMM) In vivo models of immune deficiency by homologous recombination in embryonic stem cells. Tiffany Horng, Ph.D., Assistant Professor of Genetics and Complex Diseases, Department of Genetics and Complex Diseases, HSPH (BPH) Focus is on the transcriptional mechanisms that regulate inflammatory gene expression. S. Gokhan Hotamisligil MD, PhD, James Stevens Simmons Professor of Genetics and Metabolism, HSPH (BPH) Regulatory pathways which control energy metabolism. David J. Hunter MB, BS, MPH, ScD, Professor of Epidemiology, HSPH (BPH) Cancer epidemiology; molecular epidemiology. Phyllis Jean Kanki DVM, DSc, Professor of Pathobiology in the Faculty of Public Health, HSPH (BPH) Study of epidemiology and biological characteristics of HIV-2 in West Africa. David M. Knipe PhD, Professor of Microbiology and Molecular Genetics, HMS Mechanisms by which herpes simplex virus (HSV) undergoes a productive infection in epithelial cells and the host immune response to viral infection and the use of mutant stains of HSV as a herpes vaccine and as an AIDS vaccine vector. Lester Kobzik MD, Associate Professor of Pathology, Assistant Professor in the Department of Environmental Science and Physiology, BWH (BPH) Lung macrophage differentiation and function; flow cytometry applications for respiratory cell biology. Roberto G. Kolter PhD, Professor of Microbiology and Molecular Genetics, HMS (BBS) Molecular biology of bacterial interactions; peptide production and release; growth phase regulation of gene expression. Chih-Hao Lee, Assistant Professor of Genetics & Complex Diseases (HSPH). Nuclear lipid Tun-Hou Lee B.PH, DSc, Professor of Virology, HSPH Humoral response to retroviral infections in humans; identification of coding sequences of human retroviruses and their gene products. Marc Lipsitch Dphil, Professor of Epidemiology, HSPH (BPH) Theoretical, statistical and experimental approaches to population biology and the epidemiology of infectious diseases. Quan Lu, Ph.D., Assistant Professor of Lung Biology, Department of Environmental Health and Department of Genetics and Complex Diseases, HSPH (BPH) Developing and applying genome-wide RNAi tools to study receptor signaling and gene environment interactions. Brendan D. Manning, Assistant Professor of Genetics & Complex Diseases (HSPH). Signaling pathways underlying tumorigenesis and metabolic diseases. Matthias Marti PhD, Assistant Professor of Immunology and Infectious Diseases, HSPH (BPH-IMI) Host-pathogen interactions in malaria parasites. James Mitchell, Ph.D., Assistant Professor of Genetics and Complex Diseases, Department of Genetics and Complex Diseases, HSPH (BPH) Molecular mechanisms of lifespan extension by nutritional intervention. Joseph P. Mizgerd DSc, Associate Professor of Physiology and Cell Biology, HSPH (BPH) Regulation of acute inflammatory responses by intercellular and intracellular signaling molecules. Karl Munger PhD, Professor of Pathology, HMS (BBS, BPH, VIR) Interactions of viral oncoproteins with host cell factors and their effects on the regulation of cell growth and differentiation. Human papillomaviruses (HPVs): the cause of hyperplastic skin-lesions. Bjorn R. Olsen MD, PhD, Hersey Professor of Cell Biology, HMS (BBS, BPH) Molecular and developmental biology of extracellular matrix. Eric J.Rubin MD, PhD, Professor of Immunology and Infectious Diseases, HSPH (BPH) Virulence Factors of Mycobacteria; acquisition of virulence determinants of Vibrio cholerae; generalized transposon mutagenesis systems for bacteria. Frank Martin Sacks MD, Professor of Medicine, HMS, Professor of Medicine, HSPH (BPH) Human lipoprotein metabolism, biochemical epidemiology involving lipoproteins and fatty acids and clinical trials in cardiovascular disease. Stephanie Ann Shore PhD, Senior Lecturer of Physiology in the Faculty of Public Health, HSPH (BPH) Physiological and pharmacological aspects of bronchoconstriction. Thomas J. Smith PhD, Professor and Director of Industrial Hygiene, HSPH (BPH) Environmental exposures for studies in health effects, and investigation of the relationship between environmental exposure and internal dose. Joseph G. Sodroski MD, Professor in the Department of Cancer Biology in the Faculty of Public Health, Professor of Pathology, DFCI (BPH, IMM, VIR) Human immunodeficiency virus envelope glycoproteins; HIV-1 vaccine development. Bruce M. Spiegelman PhD, Professor of Cell Biology, DFCI (BBS, BPH) Regulation of gene expression in mammalian cell differentiation; adipose cell and tissue development; nuclear hormone receptor and basic-helix-loop-helix families of transcription factors. Marianne Wessling-Resnick PhD, Professor of Nutritional Biochemistry, HSPH (BPH, BBS) Regulation of the cellular uptake of transferrin; the role of GTP-binding proteins in endocytosis; membrane transport of iron. Walter C. Willett MD, PhD, Professor of Medicine, BWH; Fredrick Stare Professor of Epidemiology and Nutrition in the Faculty of Public Health, HSPH (BPH) Relations of dietary factors to the occurrence of human disease. Dyann F. Wirth PhD, Professor of Tropical Public Health, HSPH (BPH, BBS) Molecular genetic analysis of gene expression, trans-splicing, and homologous recombination in Leishmania enrietti.
Recent Dissertation Topics“Genetic susceptibility to UV-induced immunosuppression in the etiology of non-melanoma skin cancer” “Type I interferons in Trypanosoma cruzi infection” “Growth regulation of Mycobacterium tuberculosis in vivo and in vitro.” “Regulatory mechanisms in the Akt-mTOR signaling axis “ “Global Approach toward the Identification of Transcription Factor Substrates of F-box Proteins in S. Cerevisiae.” “Regulatory mechanisms in the Akt-mTOR signaling axis” “Elucidating the activation properties of the Th2 PAMP, Lacto-N-fucopentaose III” “Stabilization of Human Immunodeficiency Virus Type 1 Envelope Glycoprotein Conformations” |