Faculty A-L

Medical Sciences-Faculty A-L

Division of Medical Sciences

Faculty (Last Name A-L)

Programs

Affiliated Hospitals and Institutions

Kami Ahmad PhD, Assistant Professor of Biological Chemistry and Molecular Pharma­cology, HMS (BBS) Histone variants and chro­mosome biology.

Koichi Akashi MD, PhD, Associate Professor of Pathology, DCFI (IMM) Self-renewal and lineage commitment of hematopoietic stem cells.

Chester Alper MD, Professor of Pediatrics, CBR (IMM) Complement genes; immunogenetics; autoimmune diseases.

Frederick W. Alt PhD, Charles A. Janeway Professor of Genetics, CH (IMM, BBS) Gene rearrangements and lymphocyte development.

Marcus Altfeld MD, PhD, Associate Professor of Medicine, MGH (IMM) Innate and adaptive immune responses in HIV-1 infection.

David Altshuler MD, PhD, Associate Professor of Genetics, MGH (BBS) Genomic approaches to human disease genetics.

Paul J. Anderson MD, PhD, K. Frank Austen Professor of Medicine, BWH (IMM) Apoptosis and autoimmunity.

Nancy Andrews MD, PhD, George Richard Minot Professor of Pediatrics, CH (BBS) A genetic approach to iron biology.

Jonathan Arm MD, Associate Professor of Medicine, BWH (IMM) The regulation of eicosanoid generation.

Scott Armstrong MD, PhD, Assistant Professor of Pediatrics, DFCI (BBS) Genomics of leukemia.

Spyridon Artavanis-Tsakonas PhD, Kurt J. Isselbacher/Peter D. Schwartz Professor of Cell Biology MGH/E (BBS) Molecular genetics of cell interaction in development.

John A. Assad PhD, Associate Professor of Neurobiology, HMS (NSCI) Mechanisms of visual processing in the visual cortex of awake behaving monkeys.

Jon Christopher Aster MD, PhD, Associate Professor of Pathology, BWH (IMM) The role of notch signaling in lymphoid neoplasia

Dennis Ausiello MD, Jackson Professor of Clin­ical Medicine, MGH/E (BBS) Signal transduction and membrane biology.

K. Frank Austen MD, Astrazeneca Professor of Respiratory and Inflammatory Diseases, BWH (IMM) Biology of anaphylactic reactions; biochemistry of the mediator molecules; molecular cell biology of the mast cell and eosinophil.

Frederick Ausubel PhD, Professor of Genetics, MGH (BBS) Molecular biology of pathogen­esis.

Tomer Avidor-Reiss PhD, Assistant Professor in Cell Biology, HMS (BBS) Cilia; formation, function and evolution.

Dan Hung Barouch MD, Associate Professor of Medicine, BIDMC (VIR) Immunopathogen­esis of HIV-1 and the development of HIV-1 vaccine strategies.

Bruce P. Bean PhD, Professor of Neurobiology, HMS (NSCI) Neurotransmitter control of ion channels.

Jonathan R. Beckwith PhD, American Cancer Society Professor of Microbiology and Molecular Genetics, HMS (BBS) Microbiology and molecular genetics.

Alan Beggs PhD, Associate Professor of Pediat­rics, CH (BBS) Molecular genetics of human neuromuscular disease.

Samuel Behar MD, PhD, Associate Professor of Medicine, BWH (IMM) Immunity to Tuber­culosis.

David Beier MD, PhD, Professor of Medicine, BWH (BBS) Molecular genetics of human neuromuscular diseases.

Welcome W. Bender PhD, Harold T. White Professor of Biological Chemistry and Molecular Pharmacology, HMS (BBS) Drosophila molec­ular genetics.

Francine M. Benes MD, PhD, Professor of Psychiatry (Neuroscience), MCL (NSCI) Quantitative microscopic approaches are used to study neural circuitry in schizophrenia and to determine how postnatal ontogenesis may contribute to the onset of this disorder.

Gilles A. Benichou PhD, Associate Professor of Surgery, MGH (IMM) Induction and regu­lation of antigen-specific T Cell responses in auto immune diseases, transplantation, and cancer.

Laura E. Benjamin PhD, Associate Professor of Pathology, BIDMS (BBS) Molecular regula­tion of physiological versus pathological angio­genesis.

Thomas L. Benjamin PhD, Virginia and D. K. Ludwig Professorship for Cancer Research and Teaching, HMS (VIR) Cellular and molecular biology of viral oncogenes, emphasizing tumorigenesis by polyoma virus and the roles of middle T antigen, and host susceptibility and resistance genes.

Christophe Benoist MD, PhD, Professor of Medicine, JDC (IMM) T-cell development in animal models of autoimmunity disease.

Larry I. Benowitz PhD, Associate Professor of Neurosurgery, CH (NSCI) Molecular mecha­nisms underlying the development, plasticity, and regeneration of axonal connections.

Thomas G. Bernhardt PhD, Assistant Professor of Microbiology and Molecular Genetics, HMS (BBS) Bacterial cell division and cell biology.

Bradley E. Bernstein MD, PhD, Assistant Professor of Pathology, MGH (BBS) Epigenetic mechanisms in mammalian development.

Antonio C. Bianco MD, PhD, Associate Professor of Medicine, BWH (BBS) Thyroid hormone metabolism and action.

Stephen Blacklow MD, PhD, Associate Professor of Pathology, BWH (BBS) Molecular basis for specificity in protein folding and protein-protein interactions, and the identifi­cation of new receptor-ligand interactions by selection and design; the low-density lipo­protein receptor.

T. Keith Blackwell MD, PhD, Associate Professor of Pathology, CBR (BBS) Transcrip­tional regulation and cellular differentiation; protein-DNA interactions.

John Blenis PhD, Professor of Cell Biology, HMS (BBS) Cytoplasmic to nuclear signal transduction in normal and transformed cells.

Michael Demian Blower PhD, Assistant Professor of Genetics, MGH (BBS) Microtubule associated RNAs during mitosis.

Richard Blumberg MD, Professor of Medicine, BWH (IMM) T cell-epithelial cell interactions in mucosal immunity.

Marianne Boes PhD, Assistant Professor of Dermatology, BWH (IMM) Mecha­nisms underlying the unique ability of antigen presenting cells to activate naive T lymphocytes .

Vadim Bolshakov PhD, Associate Professor of Psychiatry, MCL (NSCI) Mechanisms of central synaptic transmission.

Azad Bonni MD, PhD, Associate Professor of Pathology, HMS (BBS, NSCI) Regulation of glial fate specification in the central nervous system.

Richard Born MD, Professor of Neurobiology, HMS (NSCI) Neural circuitry of primate visual cortex.

Xandra O. Breakefield PhD, Professor of Neurology, MGH/E (NSCI) Molecular etiology and gene therapy of neurologic disease.

Michael B. Brenner MD, Theodore Bevier Bayles Professor of Medicine, BWH (IMM)
Chief Division of Rheumatology, Immunology and Allergy. Antigen presentation, T lympho­cyte recognition, rheumatoid arthritis and asthma.

Dennis Brown PhD, Professor of Medicine, MGH/E (BBS) Endo- and exocytosis of membrane proteins in kidney epithelial cells.

Emery Brown MD, PhD, Massachusetts General Hospital Professor of Anaesthesia, MGH (NSCI) Statistical modeling and stochastic dynamical systems analysis of neurophysi­ologic systems.

Joan Brugge PhD, Professor of Cell Biology, HMS (BBS) Integrin adhesion receptor activation of intracellular signal transduction events involved in normal cell and tumor cell growth, survival, and cytoskeletal rearrangements.

Martha Bulyk PhD, Assistant Professor of Medi­cine, and Health Sciences and Technology, BWH (BBS) Transcriptional regulatory network analyses.

Stephen Buratowski PhD, Professor of Biolog­ical Chemistry and Molecular Pharmacology, HMS (BBS) Mechanisms of transcription initiation and mRNA capping.

Rami Burstein PhD, Associate Professor of Anaesthesia, HMS/BIDMC (NSCI) Anatomy and physiology of central pain pathway medi­ating autonomic, endocrine, and affective responses to pain.

S. Barak Caine PhD, Associate Professor of Psychology, MCL (NSCI) Behavioral pharma­cology of stimulant drugs and brain dopamine systems as they relate to psychiatric disorders.

James Campbell PhD, Assistant Professor of Dermatology (Pathology), BWH (BBS) Tissue-specific lymphocyte homing and diversity.

Lewis C. Cantley PhD, Professor of Medi­cine, BIDMC (BBS) Signal transduction (PI 3-kinase, protein kinases, and SH2 domains).

Alan Cantor MD, PhD, Assistant Professor of Pediatrics, CH (BBS) Transcription factors in hematopoiesis and leukemogenesis.

Harvey I. Cantor MD, Professor of Pathology, DFCI (IMM) T lymphocytes: development and function.

William Carlezon PhD, Associate Professor of Psychiatry, MCL (NSCI) To establish causal relationships between gene expression in the brain and motivated behavior.

Charles B. Carpenter MD, Professor of Medicine, BWH (IMM) Immunomodulation; transplantation biology.

Christopher L. Carpenter MD, PhD, Associate Professor of Medicine, BIDMC (BBS) Signal transduction in cancer and immunology.

Michael C. Carroll PhD,  Professor of Pediatrics, CBR (IMM, BBS) Understanding how complement regulates B cell response and tolerance.

Constance Cepko PhD, Professor of Genetics, HMS (BBS, NSCI, VIR) Cell fate determina­tion in the vertebrate CNS. (BBS) Molecular approaches to developmental neurobiology, using retroviral vectors for gene transfer.

Joanne Chan PhD, Assistant Professor of Surgery, CH (BBS) Dissection of angiogenic signaling in zebrafish.

Chinfei Chen MD, PhD, Assistant Professor of Neurology, CH (NSCI) Synaptic plasticity in the CNS using electrophysiological and calcium imaging techniques, as well as geneti­cally altered mouse strains.

Dong Feng Chen MD, PhD, Assistant Professor of Ophthalmology, SERI (NSCI) Molecular mechanisms that control neuronal differentia­tion, nerve growth and regeneration in the mammalian brain and retina.

Zheng-Yi Chen PhD, Assistant Professor of Neurology, MGH (NSCI) Identification of genes and functional pathways that govern the development, function and disease state of the inner ear.

Andrew J. Chess MD, Associate Professor of Medicine, MGH (BBS) Genetics, Epigenetics, Molecular Biology, Chromatin.

Kenneth Chien MD, PhD, Charles Addison and Elizabeth Ann Sanders Professor of Basic Science, MGH (BBS) Cardiovascular Stem Cells in Development and Disease.

Lynda Chin MD, Associate Professor of Derma­tology, DFCI (BBS) Genetics and genomics; tumor maintenance; mouse models.

James Chou PhD, Assistant Professor of Biolog­ical Chemistry and Molecular Pharmacology, HMS (BBS) Protein NMR spectroscopy of membrane protein.

George M. Church PhD, Professor of Genetics, HMS (BBS) Mammalian and bacterial chromosomes and genomes; DNA-protein interactions and sequencing technology.

Karen Cichowski PhD, Assistant Professor of Medicine, BWH (BBS) Combining genetic and biochemical approaches to dissect tumor sup pressor gene function.

David Clapham MD, PhD, Aldo R. Castaneda Professor of Cardiovascular Research, CH (NSCI, BBS) Investigation of receptors, G proteins, ion channels, and intracellular calcium.

Jon Clardy PhD, Professor of Biological Chem­istry and Molecular Pharmacology, HMS (BBS)
Biologically active small molecules.

Donald Coen PhD, Professor of Biological Chemistry and Molecular Pharmacology, HMS (BBS, VIR) Molecular analyses of herpes viruses, stressing regulation of gene expression, DNA polymerase mechanisms, antiviral drug targets and viral latency.

David E. Cohen MD, PhD, Associate Professor of Medicine & Health Sciences and Technology, BWH (BBS) Mechanisms of hepatic choles­terol elimination.

Jonathan B. Cohen PhD, Professor of Neurobiology, HMS (NSCI, BBS) Structure and function of ligand-gated ion channels.

Monica Colaiacovo PhD, Assistant Professor of Genetics, NRB (BBS) Research on mechanisms underlying meiotic chromosome segregation.

R. John Collier PhD, The Maude and Lillian Presley Professor of Microbiology and Molecular Genetics, HMS (BBS) Protein structure and function; bacterial exotoxins; protein-membrane interactions.

Tucker Collins MD, PhD, S. Burt Wolbach Professor of Pathology, CH (BBS) Zinc finger transcription factors.

David P. Corey PhD, Professor of Neurobiology, HMS (NSCI) Physiology and cell biology of transduction and adaptation in the inner ear.

Gabriel Corfas PhD, Associate Professor of Neurology, CH (NSCI) Molecular mechanisms of neuron - glia interactions and neuronal migration.

Douglas Cotanche PhD, Associate Professor of Otology and Laryngology, CH (NSCI) Hair cell regeneration in the avian cochlea; develop­ment of the cochlear sensory epithelium.

Clyde S. Crumpacker II MD, Professor of Medicine, BID (VIR) Structure and function of herpesvirus DNA polymerase and the HIV reverse transcriptase; resistance to antiviral drugs in clinical viral isolates and mechanisms of resistance and pathogenesis.

James Cunningham MD, Associate Professor of Medicine, BWH (VIR) Host-retrovirus interac­tions, retrovirus entry, and assembly.

Charles Andrew Czeisler MD, PhD, Frank Baldino, PhD, Professor of Sleep Medicine, BWH (NSCI) The neurobiology of the human circadian pacemaker and its entrainment via retinohypothalamic photic input.

Patricia A. D’Amore PhD, Professor of Opthalmology SERI (BBS) Growth control in the vasculature.

Alan D’Andrea MD, Alvan T. and Viola D. Fuller American Cancer Society Professor of Radiation Oncology, DFCI (BBS, VIR) Receptor structure and EPO-induced signal transduction and Fanconi Anemia research. Role of viral oncogenes in signal transduction and in leukemogenesis.

George Daley MD, PhD, Associate Professor of Biological Chemistry and Molecular Phar­macology, CH (BBS) Stem cells in disease and development.

Nika Danial PhD, Assistant Professor of Pathology, DFCI (BBS) Integration of cellular metabolism and apoptosis.

Alan J. Davidson PhD, Assistant Professor of Medicine, MGH (BBS) Organogenesis of the Blood and Kidney.

James DeCaprio MD, Associate Professor of Medicine, DFCI (VIR, BBS) Role of the retinoblastoma and related proteins in SV40 T antigen and Ad E1a mediated transformation; molecular biology of fission yeast S. pombe. DNA tumor virus-mediated cellular transfor­mation; cell cycle regulation.

Ron DePinho MD, Professor of Medicine, DFCI (BBS) Focus on mechanisms governing normal cell growth, cancer, and aging.

Ronald C. Desrosiers PhD, Professor of Microbiology and Molecular Genetics, NERPRC (VIR) Primate retroviruses and herpesviruses; molecular basis for the pathoge­nicity of these viruses in primates; molecular determinants of AIDS pathogenesis.

Charles J. Dimitroff PhD, Assistant Professor of Dermatology, BWH (IMM) Studies on traf­ficking of lymphocytes to skin and of tumor cells to organ-specific sites of metastasis.

Martin Dorf PhD, Professor of Pathology, HMS (IMM) Inflammatory responses in the central nervous system; chemokines genes; chemokine receptors.

Philip R. Dormitzer MD, PhD, Assistant Professor of Pediatrics, CH (VIR) Virologic biochemical and structural approaches used to study rotavirus cell entry and develop struc­ture-based recombinant antigens for immuni­zation against rotavirus.

Simon Dove PhD, Assistant Professor of Pediat­rics, CH (BBS) The regulation of gene expres­sion in pathogenic bacteria.

John Dowling PhD, Llura and Gordon Gund Professor of Neurosciences, Harvard College Professor, HU-Camb (NSCI) Neuronal interac­tions within the retina; processing of visual information; development of the retina.

Glenn Dranoff MD, Associate Professor of Medicine, DFCI (IMM) Development of cancer vaccine.

Catherine Dulac PhD, Professor of Molecular and Cellular Biology; Howard Hughes Medical Institute Investigator, HU (NSCI) Olfactory and vomeronasal systems, molecular and developmental neurobiology.

Susan Dymecki MD, PhD, Associate Professor of Genetics, HMS (BBS, NSCI) Site-specific recombinase technology, transgenics, inser­tional mutagenesis, and cDNA analyses to study organogenesis in the mouse; genetic control of neural development; neural patterning in the developing mouse embryo.

Nicholas John Dyson PhD, Professor of Medi­cine, MGH/E (BBS, VIR) Control of cell proliferation by RB/E2F.

Ruth A. Eatock PhD, Associate Professor of Otology and Laryngology, MEEI (NSCI)
Sensory Transduction, Tuning and Transmis­sion by Hair Cells and Afferent Neurons of the Inner Ear.

Michael Eck MD, PhD, Associate Professor of Biological Chemistry and Molecular Pharma­cology, DFCI (BBS) Structure biology of cyto­plasmic signal transduction.

Ulrike Sophie Eggert PhD, Assistant Professor of Biological Chemistry and Molecular Pharma­cology, DFCI (BBS) Chemical approaches to cell division.

Elaine Elion PhD, Professor of Biological Chem­istry and Molecular Pharmacology, HMS (BBS) Molecular mechanisms of signal transduction.

Stephen Elledge PhD, Gregor Mendel Professor of Genetics and of Medicine, NRB (BBS) Cell cycle control and genomic integrity.

Alan Engelman PhD, Associate Professor of Pathology, DFCI (VIR) Retroviral DNA inte­gration; recombinant viral integrase enzyme activities in vitro; structure of the HIV-1 preintegration subviral complex that forms during infection. Enzymology of retroviral integrase proteins; functional organization of retroviral preintegration complexes.

Florian Engert PhD, Assistant Professor of Molecular and Cellular Biology, HU-Camb (NSCI) Synaptic plasticity: cellular mecha­nisms, development of functional networks and links to behavior.

Elizabeth Engle MD, Associate Professor of Neurology, CH (NSCI) Molecular basis of inherited congenital eye movement disorders and implications for the development of brain­stem motorneurons.

Raymond Erikson PhD, American Cancer Society Professor of Cellular and Developmental Biology, HU (VIR) Protein phosphorylation and gene expression in normal and trans­formed cells.

Myron Essex DVM, PhD, John Laporte Given Professor of Infectious Diseases, HSPH (VIR)
Study of human and primate T-lymphotrophic retroviruses, including agents that cause AIDS. Role of viruses in the causing of cancer and AIDS; pathogenesis and evolutionary epidemi­ology of human retroviruses.

David T. Evans PhD, Assistant Professor of Microbiology and Molecular Genetics, NERPRC (BBS) Primate lentiviral immunology and pathogenesis.

Mark A. Exley PhD, Assistant Professor of Medicine, BIDMC (IMM) NKT and Other Immune Cell Subsets in Anti-Tumor & Anti-Viral Immunity.

Michela Fagiolini PhD, Assistant Professor of Neurology, CH (NSCI) Epigenetic control of experience-dependent neuronal circuit matu­ration and plasticity.

Michael Farzan PhD, Assistant Professor of Microbiology and Molecular Genetics, NERPC (BBS, VIR) Entry mechanisms of, and the humoral response to, HIV-1 and other viruses.

Mel Feany MD, PhD, Associate Professor of Pathology, BWH (BBS, NSCI) Models human neurodegenerative diseases in the fruit fly Drosophilia.

Joyce Fingeroth MD, Associate Professor of Medicine, BIDMC (VIR) Immunobiology of the Epstein-Barr virus receptor; pathogenesis of EBV and B-cell tumors.

Daniel J. Finley PhD, Professor of Cell Biology, HMS (BBS) Protein modification by ubiqitin.

David Erich Fisher MD, PhD, Professor of Pediatrics, DFCI (BBS) Apoptosis in tumori­genesis and cancer therapy; protein::DNA interactions in cell growth and development.

John Flanagan PhD, Professor of Cell Biology, HMS (BBS, NSCI) Function of cell-cell signaling molecules in establishing precise special order in neural development.

Mark Fleming MD, DPhil, Associate Professor of Pathology, CH (BBS) Molecular genetics of erythroid iron metabolism.

David A. Frank MD, PhD, Assistant Professor of Medicine, DFCI (BBS) Intracellular signaling pathways in the regulation of cell growth and differentiation.

Michael Freeman PhD, Associate Professor of Surgery, CH (BBS) Growth factors and signal transduction.

Dana Helga Gabuzda MD, Professor of Neurology, DFCI (VIR) Molecular biology of HIV; Chemokine receptors and HIV patho­genesis in the nervous system; mechanisms of apoptosis in AIDS.

Guillermo Garcia-Cardena PhD, Assistant Professor of Pathology, NRB (BBS) Control of endothelial cell fate and vascular development by fluid mechanical forces.

Rachelle Gaudet PhD, Associate Professor of Molecular and Cellular Biology, HU (NSCI) Structural biology of signaling and transport through biological membranes.

Raif S. Geha MD, James L. Gamble Professor of Pediatrics, CH (IMM) Regulation of IgE responses; molecular basis of immunodeficien­cies.

Lee Gehrke PhD, Professor of Health Sciences and Technology, HMS (BBS, VIR) RNA-protein interactions/translational control/RNA viruses.

Niels Geijsen PhD, Assistant Professor of Medi­cine, MGH (BBS) Germ cell development, pluripotency and epigenetic reprogramming.

Katia Georgopoulos PhD, Professor of Derma­tology, MGH (IMM) Transcription factors in lymphocyte commitment and differentiation.

D. Gary Gilliland MD, PhD, Professor of Medicine, BWH (BBS, IMM) Molecular genetics of human leukemias.

Michael A. Gimbrone Jr. MD, Elsie T. Friedman Professor of Pathology, BWH (BBS) Endothelial cell biology and the molecular pathogenesis of vascular disease.

Laurie H. Glimcher MD, Professor of Medicine, BWH; Irene Heinz Given Professor of Immunology, HSPH (IMM) Genetic programs in T helper cell differentiation.

David E. Golan MD, PhD, Professor of Bio logical Chemistry and Molecular Pharma­cology, HMS (BBS) Dynamics of membrane proteins; signal transduction across membranes; molecular mechanisms in cell-cell interaction.

Alfred L. Goldberg PhD, Professor of Cell Biology, HMS (BBS) Regulation and mecha­nisms of intracellular protein breakdown.

Marcia Goldberg MD, Associate Professor of Medicine (Microbiology), MGH (BBS) Pathogen-Host Interactions.

Anne E. Goldfeld MD, Associate Professor of Medicine, CBR (IMM) Regulation of TNF-alpha gene expression; immuno­pathogenesis of tuberculosis and AIDS.

Daniel A. Goodenough PhD, Takeda Professor of Cell Biology, HMS (BBS) Intercellular communication.

Lisa Goodrich PhD, Assistant Professor of Neurobiology, HMS (NSCI, BBS) A combina­tion of genetic, molecular and embryological approaches investigating the auditory system.

Nathanael Gray PhD, Assistant Professor of Biological Chemistry and Molecular Pharma­cology, DFCI (BBS) Functional small molecules for biological discovery.

Michael Greenberg PhD, Professor of Neurobi­ology, CH (BBS, NSCI, VIR) Neurotransmitter and neurotrophin regulation of immediate early gene transcription, signal transduction in the nervous system. Mechanisms of proto­oncogene regulation during cell proliferation and neuronal differentiation in animal cells.

Richard Ian Gregory PhD, Assistant Professor of Biological Chemistry and Molecular Phar­macology, CH (BBS) Mechanisms of RNAi in stem cells.

Michael Grusby PhD, Associate Professor of Medicine, HSPH (IMM) Regulation of T helper cell differentiation.

Chenghua Gu PhD, Assistant Professor of Neurobiology, HMS (NSCI, BBS) The Molec­ular mechanisms of how neural and vascular networks are coordinately developed, commu­nicate and evolve to work in concert during normal and disease states.

James F. Gusella PhD, Bullard Professor of Neurogenetics, MGH (BBS) Genetic analysis of human inherited diseases.

Emanuela Gussoni PhD, Assistant Professor of Pediatrics, CH (BBS) Muscle stem cell commitment and differentiation.

Steven Gygi PhD, Associate Professor of Cell Biology, HMS (BBS) Mass spectrometry and proteomics.

Daniel A. Haber MD, PhD,  Lauren Schwartz Professor of  Medicine, MGH/E (BBS) Char­acterization of the Wilms tumor suppressor gene (WT1); isolation of gene for x-linked lympholiferative syndrome; analysis of BRCAI germline mutation.

Nir Hacohen PhD, Assistant Professor of Medicine, MGH (IMM) Dendritic cells and the initiation of immune reponses; Genetic analysis using genome-wide mammalian RNAi libraries.

David A. Hafler MD, Jack, Sadie, and David Breakstone Professor of Neurology (Neuroscience) BWH (IMM) Autoimmunity, immunology of neurologic diseases.

William Hahn MD, PhD, Associate Professor of Medicine, DFCI (BBS) Molecular approaches to cell immortalization and transformation.

Marcia C. Haigis PhD, Assistant Professor of Pathology, HMS (BBS) Mitochondria in aging and metabolism.

Edward Harlow PhD, Professor and Chair of Biological Chemistry and Molecular Pharma­cology, HMS (BBS, VIR) Function of tumor suppressor gene products; mammalian cell cycle control. Tumor suppressor gene func­tion; transformation by DNA tumor viruses; eukaryotic cell cycle control. (VIR)

Donald Alfred Harn Jr. PhD, Professor of Tropical Public Health, HSPH (IMM) Studies how a specific family of oligosaccharides found in human milk, as well as on pathogens, drive various immune effector cells to a polarized Th2-type immune response. Applications of these compounds to treat autoimmune diseases also investigated.

J. Wade Harper PhD, Bert and Natalie Vallee Professor of Molecular Pathology, HMS (BBS) Cell cycle control and ubiquitin-mediated proteolysis.

Stephen Harrison PhD, Professor of Biological Chemistry and Molecular Pharmacology, HMS (BBS, VIR) Macromolecular assembly; virus structure; X-ray diffraction. Virus structure and assembly; viral entry; X-ray crystallography.

Anne Hart PhD, Associate Professor of Pathology, MGH/E (BBS, NSCI) Analysis of sensory signal transduction, neuropeptide neurotransmitters and polyglutamine diseases (like Huntington’s) in C. elegens.

Xi He PhD, Associate Professor of Neurology, CH (BBS) Signal transduction in vertebrate development.

Zhigang He PhD, Associate Professor of Neurol ogy, CH (NSCI) Cellular and molecular mechanisms in axon guidance and regenera­tion.

Martin E. Hemler PhD, Professor of Pathology, DFCI (IMM) Structures and functions of molecules involved in cell adhesion and cell migration.

Darren Higgins PhD, Associate Professor of Microbiology and Molecular Genetics, HMS (BBS) Mechanisms of growth and spread of intracellular bacterial pathogens; identification of pathogen-specific antigens required for T-lymphocyte recognition.

Jonathan M.G. Higgins PhD, Assistant Professor of Medicine, BWH (BBS) Mitotic kinases, chromatin and chromosome segregation.

Martin S. Hirsch MD, Professor of Medicine, MGH (VIR) Pathogenesis and treatment of human retrovirus and herpes virus infection.

Joel Hirschhorn MD, PhD, Associate Professor of Genetics, CH (BBS) Genomics and complex genetic traits.

I-Cheng Ho MD, PhD, Associate Professor of Medicine, BWH (IMM) Transcriptional regulation of T lymphocyte activation and differentiation.

Ann Hochschild PhD, Professor of Microbiology and Molecular Genetics, HMS (BBS) Gene regulation of prokaryotes.

Hanno R. Hock MD, PhD, Assistant Professor of Medicine, MGH (BBS) Transcriptional control of hematopoiesis and leukemia.

James Hogle PhD, Edward S. Harkness Professor of Biological Chemistry and Molecular Pharmacology, HMS (BBS, VIR) X-ray crys­tallo graphic studies of viruses and viral proteins. Structure and function of viruses and virus-related proteins; X-ray crystallography.

Bruce Horwitz MD, PhD, Assistant Professor of Pediatrics CH (IMM) The role of the tran­scription factor NF-kB in regulating innate inflammatory responses.

Peter M. Howley MD, Shattuck Professor of Pathological Anatomy, HMS (BBS, VIR) Viral pathogenic and transformation mechanisms.

Victor W. Hsu MD, Associate Professor of Medicine, BWH (BBS) Basic and applied mechanisms of intracellular transport.

Guo-Fu Hu PhD, Assistant Professor of Pathology, HMS (BBS) Mechanism and regula­tion of ribosome biogenesis.

Deborah Tan Hung MD, PhD, Assistant Professor of Microbiology and Molecular Genetics, HMS (BBS) Chemical genetics approach to bacterial pathogenesis.

Bradley Theodore Hyman MD, PhD, John B. Penny Jr., Professor of Neurology (Neuroscience), MGH (NSCI) Studying the pathophysiology of Alzheimer’s disease by studying the anatom­ical and functional changes of the brain, and the molecular alterations that underlie these changes.

John Iacomini PhD, Associate Professor of Surgery, MGH (IMM) Induction of immunological tolerance by gene therapy.

Donald E. Ingber MD, PhD, Judah Folkman Professor of Vascular Biology, CH (BBS) Control of growth and differentiation by extracellular matrix.

Ole Isacson Dr. Med. Sci., MB, Professor of Neurology, MCL (NSCI) Mechanisms involved in neuronal degeneration and regen­eration in the adult central nervous system, particularly as they relate to Parkinson’s, Huntington’s, and Alzheimer’s diseases.

Joseph E. Italiano PhD, Assistant Professor of Medicine, BWH (BBS) Cytoskeletal mechanics of blood platelet production.

Laurie Jackson-Grusby PhD, Assistant Professor of Pathology, CH (BBS) Epigenetic regulation in development and disease.

Frances Jensen MD, Associate Professor of Neurology, CH (NSCI) Age-dependent mecha­nisms of perinatal brain injury.

Ru-Rong Ji PhD, Associate Professor of Anes­thesia, BWH (NSCI) Neural-glial interaction for the development and maintenance of chronic pain.

Robert P. Johnson MD, Associate Professor of Medicine, NERPRC (IMM) AIDS Immunopatho genesis and Immune  Recon stitution.

Welkin E. Johnson PhD, Assistant Professor of Microbiology and Molecular Genetics, NERPRC (BBS, VIR) Molecular biology and evolution of retroviruses.

J. Keith Joung MD, PhD, Assistant Professor of Pathology MGH (BBS) Molecular recognition and protein engineering.

Jae Jung PhD, Professor of Microbiology and Molecular Genetics, NERPRC (BBS, VIR) Molecular mechanism of herpes virus onco­genesis; herpes virus as gene transfer vector. Molecular analysis of pathogenesis associated with Herpesvirus Saimir and Kaposi’s sarcoma-associated herpesvirus.

C. Ronald Kahn MD, Mary K. Iacocca Professor of Medicine, JDC (BBS) Molecular mechanisms of insulin action and insulin resistance; insulin-like growth factors; genetics of diabetes mellitus; signaling molecules and their alterations in diabetes.

Daniel Kahne PhD, Professor of Biological Chemistry and Molecular Pharmacology HMS (BBS) Antibiotic resistance and organelle assembly.

Raghu Kalluri MD, PhD, Associate Professor of Medicine, BIDMC (BBS) Matrix biology, cell-matrix interactions in health and disease.

Yoshihide Kanaoka MD, PhD, Assistant Professor of Medicine, BWH (IMM) The role of cys-Lts in antigen-induced pulmonary inflammation and the mechanism of cys-LT­mediated pulmonary fibrosis.

Joshua M. Kaplan PhD, Professor of Genetics, MGH (BBS, NSCI) Intracellular signaling, neurobiology, protein transport/trafficking and secretion, signal transduction.

Dennis Kasper MD, William Ellery Channing Professor of Medicine, BWH (BBS) Bacterial/ host interactions in symbiosis and pathogen­esis.

Howard Raymond Katz PhD, Associate Professor of Medicine, BWH (IMM) Regulation of mast cell activation by cell surface receptors of the Immunoglobulin Superfamily.

Kenneth Kaye MD, Associate Professor of Medicine, BWH (VIR) Molecular biology of Kaposi’s Sarcoma-associated herpes virus.

Andrius Kazlauskas PhD, Associate Professor of Ophthalmology, SERI (BBS) Elucidating the signal transduction cascades by which receptor tyrosine kinases initiate biological responses such as chemotaxis, apoptosis, proliferation, and differentiation.

Raymond J. Kelleher MD, PhD, Assistant Professor of Neurology, MGH (NSCI) Molecular and Cellular Mechanisms of Cognition and Cognitive Disorders, Particularly the Role of Translational Regulation.
Vicki Rubin Kelley PhD, Associate Professor of Medicine (Pathology), BWH (IMM) Mechanisms of autoimmune disease.

Roya Khosravi-Far PhD, Associate Professor of Pathology, BIDMC (BBS) Signal transduction pathways involved in cellular proliferation and apoptosis.

Elliott Kieff MD, PhD, Harriet Ryan Albee Professor of Medicine, BWH (BBS, IMM, VIR) Epstein-Barr Virus B lymphocyte growth and differentiation. Molecular cellular biology of lymphocyte growth transformation by Epstein-Barr virus; transcriptional regulation through the Notch Pathoway and signal trans­duction by TNF receptors.

Carla Kim PhD, Assistant Professor of Genetics, CH (BBS) Lung stem cell biology and cancer.

Kwang-Soo Kim PhD, Associate Professor of Psychiatry, MCL (NSCI) Investigation of central nervous system pathways regulating autonomic and neuroendocrine function.

Jean-Pierre Kinet MD, Professor of Pathology, BIDMC (IMM) Biology and Function of Immunoreceptors.

Randy King MD, PhD, Associate Professor of Cell Biology, HMS (BBS) Chemical approaches to cell division and cancer.

Robert E. Kingston PhD, Professor of Genetics, MGH (BBS, VIR) Mammalian transcription; role of chromatia and regulation by heat.

Tomas L. Kirchhausen PhD, Professor of Cell Biology, CBR (BBS) Structural biochemistry and cell biology of intracellular membrane traffic.

Marc W. Kirschner PhD, Professor of Systems Biology, HMS (BBS) Cell cycle regulation, early development, cytoskeletal organization.

Michael Klagsbrun PhD, Patricia K. Donahoe Professor of Surgery, CH (BBS) Growth factor structure and function.

Nancy E. Kleckner PhD, Herchel Smith Professor of Biology, HU (VIR) Genetics and biochemistry of bacterial transposons, bacterial replication initiation, and yeast meiotic chro­mosome metabolism.

David M. Knipe PhD, Higgins Professor of Microbiology and Molecular Genetics, HMS (VIR, BBS) Molecular biology of herpes simplex virus; regulation of viral gene expres­sion; mechanisms of latent infection and host immune response.

Koichi S Kobayashi MD, PhD, Assistant Professor of Pathology, DFCI (IMM) Using biochemical, cellular and mouse genetics approaches to dissect the innate immune signaling pathways of Toll-like receptors and NBD-LRR (Nod) proteins.

Christine Kocks PhD, Assistant Professor of Pediatrics, MGH (IMM) Microbial pattern recognition and signaling in innate immunity.

Roberto G. Kolter PhD, Professor of Microbiology and Molecular Genetics, HMS (BBS) Molecular biology of bacterial interactions; peptide production and release; growth phase regulation of gene expression.

Stella Kourembanas MD, Clement A. Smith Associate Professor of Pediatrics, CH (BBS)
Molecular basis of pulmonary hypertension, hypoxic signaling, and lung vascular develop­ment.

Edward A. Kravitz PhD, George Packer Berry Professor of Neurobiology, HMS (NSCI)
Hormonal orchestration of behavior.

Jordan Kreidberg MD, PhD, Associate Professor of Pediatrics, CH (BBS) Signaling networks in development and disease.

Raju Kucherlapati PhD, Paul C. Cabot Professor of Genetics, HMS (BBS) Genetics and genomics of human disease.

Vijay Kumar Kuchroo PhD, Samuel L. Wasser­strom Professor of Neurology, BWH (IMM) Cellular and genetic factors involved in the induction and regulation of autoimmunity.

Rohit Kulkarni PhD, Assistant Professor of Medicine, JDC (BBS) Stem cells, islet cell func­tion, growth, and development.

Sam Kunes PhD, Professor of Molecular and Cellular Biology, HU-Camb (NSCI) Nervous system construction and function.

Louis M. Kunkel PhD, Professor of Pediatrics, CH (BBS, NSCI) Molecular basis of human neuromuscular disease.

Daniel Kuritzkes MD, Professor of Medicine, BWH (VIR) Mechanisms of antiretroviral drug resistance, and drug resistant human immuno­deficiency virus.

Mitzi Kuroda PhD, Professor of Genetics, HMS (BBS) Molecular genetics of chromosome organization and gene expression.

David Kwiatkowski MD, PhD,  Professor of Medicine, BWH, (BBS) Human, molecular, and mouse genetics.

Lois A. Lampson PhD, Associate Professor of Surgery, BWH (NSCI) Immunobiology of the nervous system and its tumors.

Peter Lansbury PhD, Professor of Neurology, BWH (BBS) The biochemistry of Alzheimer’s disease.

Andrew Lassar PhD, Professor of Biological Chemistry and Molecular Pharmacology, HMS (BBS) Molecular mechanisms that regulate cell fate determination and differentiation in vertebrates.

Phillipe Leboulch PhD, Associate Professor of Medicine, BWH (BBS) Vectorology of chromo­somal integration and gene therapy models.

Philip Leder MD, John Emory Andrus Professor of Genetics, BWH (BBS) Structural, regulatory, and developmental analysis of genes that affect cell growth; analysis of oncogenes in transgenic mice.

Jeannie Lee MD, PhD, Professor of Genetics, MGH (BBS) Molecular genetics of X-chro­mosome inactivation, a whole chromosome silencing phenomenon that enables female (XX) and male (XY) cells to achieve equal X-chromosome transcription in spite of their differing X-chromosome constitution.

Tun-Hou Lee BPh, DSc, Professor of Virology, HSPH (VIR) Humoral response to retroviral infections in humans; identification of coding sequences of human retroviruses and their gene products. Role of human and related primate retroviruses; encoded gene products in disease pathogenesis.

Wayne Lencer MD, Associate Professor of Pediatrics CH (BBS) Bacterial toxin entry and immunoglobulin transport in mucosal epithe­lial cells.

Cammie Lesser MD, PhD, Assistant Professor of Medicine, MGH (BBS) Modeling mecha­nisms of bacterial pathogenesis.

Anthony G. Letai MD, PhD, Assistant Professor of Medicine, DFCI (BBS) Targeting apoptosis regulation in cancer.

Norman Letvin MD, Professor of Medicine, BIDMC (IMM, VIR) Immune response to human and primate retroviruses. T lympho­cyte-mediated immunity to AIDS viruses in nonhuman primates and man.

Michael Levin PhD, Assistant Professor of Developmental Biology, FORS (BBS) The biophysics and molecular genetics of biological information flow. We use the contexts of morphogenesis in chick and frog embryos, and regeneration in flatworms, to understand how ion flux and gap-junctional communication underlies signal exchange between cells. We also investigate the molecular basis of memory in flatworms.

Andrew Lichtman MD, PhD, Associate Professor of Pathology, BWH (IMM) Lympho­cyte-endothelial interactions; T cell cytokine gene regulation; immunopathology of blood vessel walls.

Jeff Lichtman MD, PhD HU (NSCI) Professor of Molecular and Cellular Biology The study of synaptic competition by visualizing synaptic rearrangements directly in living animals using modern optical techniques.

Judy Lieberman MD, PhD, Professor of Pedi­atrics, CBR (BBS, IMM, VIR) Mechanism of CTL-induced cell death and CTL response to HIV-1.

David Livingston MD, Emil Frei Professor of Medicine, DFCI (BBS, VIR) Molecular biology of DNA tumor virus-transformation; mecha­nism of oncogene and antioncogene product action in vivo and in vitro; cell-cycle control mechanism analysis.

Margaret S. Livingstone PhD, Professor of Neurobiology, HMS (NSCI) Anatomical and physiological studies of the primate visual system.

Eng Lo PhD, Professor of Radiology, MGH (NSCI) Mechanisms of cell death in stroke and trauma.

Mary Loeken PhD, Associate Professor of Medicine (Physiology), JDC (NCSI) Tran­scription regulation during mammalian neural tube development.

A. Thomas Look MD, Professor of Pediatrics, DFCI (BBS, IMM) Genetic models of Leukemo­genesis.

Stephen Lory PhD, Professor of Microbiology and Molecular Genetics, HMS (BBS) Host pathogen interactions.

Bradford B. Lowell MD, PhD, Professor of Medicine, BIDMC (NSCI) Genetic engi­neering in mice is used to investigate neuro­circuits thought to regulate metabolism and behavior.

Kun Ping Lu MD, PhD, Associate Professor of Medicine, BIDMC (BBS) Cell Growth Regulation, Telomere Maintenance and Human Diseases.

Hongbo Luo PhD, Assistant Professor of Pathology, CH (BBS) Signaling in innate immunity and leukemia.

Francis Luscinskas PhD, Associate Professor of Pathology, BWH (IMM) Cell biology, biochemistry and immunology of leukocyte­endothelial adhesion.

Andrew David Luster MD, PhD, Professor of Medicine, MGH/E (IMM) Basic biology and pathobiology of the chemokine superfamily of chemotactic cytokines.